Researchers from the Hebrew University of Jerusalem find about the process of bacterial Infection in our intestinal tract caused by E. coli bacteria. They studied that this bacterium remodeled specific genes expressions after sensing their attachment with their host's intestine cell. Those specific genes those are involved in virulence and metabolism are remodeled.
Diarrhea is one of most common disease mostly affected by children as well as adults. There is a statistic released by World Health organization or WHO, which showed up that they recorded 1.7 billion cases of diarrheal disease around the globe in every year. Though this disease is both treatable as well as preventable but they also stated that every year, around 760000 infant under age five have died due to this disastrous disease.
Though there are several reasons but the principle cause belongs to such devastating disease is a bacterial infection in gastrointestinal tract caused by enteropathogenic bacteria. The name of that bacterium is Escherichia coli or E. coli. The main source by which that bacterium entered to the body is consuming contaminated materials within water or food.
Recently the latest research paper published in Science journal by the faculty of Medicine in Hebrew University of Jerusalem or HUJ. On that paper, they described the reaction of a pathogen after sensing about their host and remodeled their gene expression and then exploit their host which resulted in an infection. This whole research is led by Prof. Ilan Rosenshine professor of Bacteriology at the Hebrew University of Jerusalem.
Based on a detailed analysis by The Hebrew University of Jerusalem, researchers demonstrates these bacteria and their gene expression after sensing their attachment with the human intestinal cell. The whole demonstration presented through the microscope where one of these genes expresses a protein which identifies the attached bacteria which appeared in green shade and non-attached bacteria remain in dark.
A study related to this latest research also informed that the infection involves hundred of genes and proteins from both bacteria and human host. However, the whole mechanism of sensing the host cell and react by reconstructing their gene model is still unclear. Researchers are also stated that if they recognize the whole mechanism of their sensing, gene expression including metabolism and gene expression that may lead to new strategies to defend against this bacterial infection.
