On December 2022, pop superstar Celine Dion shared on Instagram that she was diagnosed with a rare neurological condition known as stiff person syndrome. It is a disease with an unknown cause, although scientists believe it is a result of an autoimmune reaction that attacks the nerve cells.
Celine Cancels World Tour
The 55-year-old singer continues to battle the one-in-a-million neurological condition. Although she initially rescheduled her tour last year, Celine Dion announced in another Instagram post that she has decided to cancel her Courage World Tour entirely. Tickets will be refunded through their original point of sale.
The singer has expressed her "tremendous disappointment" that she is canceling her shows this August through April next year. MailOnline reported that the singer was expected to perform in Europe, including Belgium, Denmark, France, and the UK.
She noted that it is not fair to keep on postponing and rescheduling shows. Though this decision breaks her heart, she believes it is the best choice until she is fully ready to be back on stage. Dion also pointed out that she is not giving up on her condition and is excited to see her fans soon.
About Stiff Person Syndrome
According to Cleveland Clinic, stiff person syndrome (SPS) is a rare autoimmune neurological disorder characterized by muscle stiffness primarily in the trunk and abdomen, with eventual rigidity and spasms extending to the legs and other muscles. This progression can lead to difficulties in walking, increased vulnerability to falls, and a higher risk of injury.
Formerly known as "stiff man syndrome," the condition underwent a name change to better encompass its impact on individuals of any age and gender. There are various subtypes or classifications of SPS, including the most common form known as classic SPS, which is associated with GAD (glutamic acid decarboxylase) antibodies.
However, studies have also identified other antibody associations. Additionally, SPS variants exist, affecting specific body parts or causing a more pronounced lack of coordination (ataxia).
A more severe variant called progressive encephalomyelitis with rigidity and myoclonus (PERM) is characterized by decreased consciousness, issues with eye movement, ataxia, and autonomic dysfunction. The management of PERM often necessitates hospital care due to autonomic dysfunction.
Diagnosis and Treatment of Stiff Person Syndrome
The condition affects more females than males and is often linked to other autoimmune diseases, as per the National Institute of Health. Diagnosing SPS can be challenging as it is frequently misdiagnosed as other conditions, like Parkinson's disease or multiple sclerosis.
However, a definitive diagnosis can be made through a blood test measuring the levels of glutamic acid decarboxylase (GAD) antibodies. Most individuals with SPS have elevated levels of GAD antibodies, with particularly high titers seen in the spinal fluid.
Treatment options for SPS aim to manage the symptoms effectively. Oral medications can help alleviate muscle spasms and anxiety, while intravenous immunoglobulin (IVIg) treatment has shown promise in reducing stiffness, sensitivity to noise, touch, and stress, as well as improving gait and balance in individuals with SPS. IVIg contains natural antibodies obtained from numerous healthy donors and is administered intravenously.
RELATED ARTICLE: Diagnosed With Stiff Person Syndrome, Celine Dion Cancels 2023 Engagement; Here's What Science Says About SPS
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