NANOTECHNOLOGY

An unexpected bonus - blocking STAT3 could help cancer patients in two ways

NANOTECHNOLOGY The STAT transcription factors are involved in the development of many forms of cancer. STAT3 is frequently activated in tumour cells, so drugs targeting STAT3 could be used in cancer therapy. However, STAT3 is also important in the development of the immune system. Dagmar Gotthardt and colleagues at the Vetmeduni Vienna now show that blocking STAT3 in cells of the immune system actually leads to increased anti-tumour immunity. Anti-STAT3 therapy may thus be highly promising.

More Treasures Come To Surface at Antikythera Wreck Site

Over a hundred years ago, in 1900, sponge divers swimming at the bottom of the sea nearest the island of Antikythera in southern Greece unearthed an extraordinary treasure from the wreckage of a once sea-ferrying ship. Known simply as the Antikythera shipwreck, over the years many artifacts have been discovered bringing to light the culture and the technology of the time the ship sank, and this year excavation efforts have revealed even more.

Long-term treatment success using gene therapy to correct a lethal metabolic disorder

Excessive and often lethal blood levels of bilirubin can result from mutations in a single gene that are the cause of the metabolic disease known as Crigler-Najjar syndrome type 1 (CNS1). A new gene therapy approach to correcting this metabolic error achieved significant, long-lasting reductions in bilirubin levels in a mouse model of CNS1 and is described in an Open Access article in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available on the Human Gene Therapy website at http://online.liebertpub.com/doi/full/10.1089/hum.2013.233.

Drug-infused nanoparticle is right for sore eyes

For the millions of sufferers of dry eye syndrome, their only recourse to easing the painful condition is to use drug-laced eye drops three times a day. Now, researchers from the University of Waterloo have developed a topical solution containing nanoparticles that will combat dry eye syndrome with only one application a week.

Coral Bleaching Near Oahu Signals Ecosystem’s Distress

With this summer bringing record-breaking heat waves throughout the northern hemisphere, the people of Hawaii have found that the lack of trade winds have made for a particularly warm and humid summer. And they’re not the only ones suffering.

Toddlers regulate behavior to avoid making adults angry

When kids say "the darnedest things," it's often in response to something they heard or saw. This sponge-like learning starts at birth, as infants begin to decipher the social world surrounding them long before they can speak.

Supervisors' abuse, regardless of intent, can make employees behave poorly

So-called motivational abuse is seen as a violation and leads to behavioral backlash So-called motivational abuse is seen as a violation and leads to behavioral backlash Employees who are verbally abused by supervisors are more likely to "act out" at work, doing everything from taking a too-long lunch break to stealing, according to a new study led by a San Francisco State University organizational psychologist.

Vesicles influence the function of nerve cells

Neurons react to the transmission activity of exosomes on three fundamental levels Neurons react to the transmission activity of exosomes on three fundamental levels Tiny vesicles containing protective substances which they transmit to nerve cells apparently play an important role in the functioning of neurons.

Scientists discover pain receptor on T-cells

Researchers at University of California, San Diego School of Medicine have discovered that T-cells - a type of white blood cell that learns to recognize and attack microbial pathogens - are activated by a pain receptor.

Scientists develop barcoding tool for stem cells

New technology that tracks the origin of blood cells challenges scientific dogma New technology that tracks the origin of blood cells challenges scientific dogma A 7-year-project to develop a barcoding and tracking system for tissue stem cells has revealed previously unrecognized features of normal blood production: New data from Harvard Stem Cell Institute scientists at Boston Children's Hospital suggests, surprisingly, that the billions of blood cells that we produce each day are made not by blood stem cells, but rather their less pluripotent descendants, called progenitor cells.
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